Happy New Year πŸŽ‰

We are kicking off the new year with a great selection of articles. In this week's episode, we review the OPTIMIST-A trial and discuss whether minimally invasive surfactant treatment will eventually replace InSurE. We also discuss two interesting papers about early markers of gut injury in anemia and how a baby's sex influences the appropriate threshold for blood transfusion. Finally, we reviewed a paper from πŸ‡ΈπŸ‡ͺ that studied how eye tracking technology and testing done at four months corrected GA can predict ADD and cognititve outcomes at 6-7 years of life.

Enjoy this journal club and let us know if you have any feedback or recommendations.

As mentioned during the episode, Dr. Keith Barrington's blog post summarizing the various trials discussing transfusions thresholds in nicu babies is so well written and summarizes the evidence so well, that it is worth sharing:

When should we transfuse preterm babies, and why? Redux.
The TOP trial has just been published in the FPNEJM (Kirpalani H, et al. Higher or Lower Hemoglobin Transfusion Thresholds for Preterm Infants. N Engl J Med. 2020;383(27):2639-51). It was a multice…

Articles discussed in this week's episode are listed below (in chronological order).

Effect of Minimally Invasive Surfactant Therapy on Death or Bronchopulmonary Dysplasia in Preterm Infants
This randomized clinical trial includes preterm infants with a gestational age of 25 to 28 weeks who were supported with continuous positive airway pressure and compares the effect of selective application of minimally invasive surfactant therapy at a low fraction of inspired oxygen threshold vs...
Neonatal anemia relates to intestinal injury in preterm infants - Pediatric Research
Pediatric Research - <ArticleTitle Language="En" xml:lang="en">Neonatal anemia relates to intestinal injury in preterm...
Sex Differences in the Association of Pre-Transfusion Hemoglobin Levels with Brain Structure and Function in the Preterm Infant
To assess sex-specific differences in early brain structure and function of preterminfants after red blood cell (RBC) transfusions.
Maternal and Neonatal SARS-CoV-2 Antibody Levels at Delivery After mRNA COVID-19 Vaccination
This cohort study evaluates maternal and neonatal COVID-19 antibody levels at delivery after receipt of a messenger RNA (mRNA) COVID-19 vaccine during the second trimester of pregnancy.
Visual tracking at 4 months in preterm infants predicts 6.5-year cognition and attention - Pediatric Research
Pediatric Research - <ArticleTitle Language="En" xml:lang="en">Visual tracking at 4 months in preterm infants predicts 6.5-year cognition and...

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